Asian Journal of Research in Chemistry

S. Ganapathy ¹, G. V. H. Raju ¹, D. G. Sankar ¹, Pettla Y. Naidu ¹

Affiliations
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, IN

Abstract

A three simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Levetiracetam (LEVT) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Levetiracetam (LEVT) with 3-Methyl-2-benzo thiazolinone hydrazone (MBTH) and Cerric Ammonium Sulphate (CAS). Method B is based on the formation of colored species on treatment of Levetiracetam (LEVT) with Fecl₃ and 1,10 PTL. Method C represents UV Spectrophotometric determination of Levetiracetam and its dosage forms in Methanol at 210 nm.

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S. Ganapathy ¹, D. G. Sankar ¹, Pettla Y. Naidu ¹

Affiliations
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, IN

Abstract

A simple, sensitive and reproducible spectrophotometric method was developed for the determination of Gemifloxacin (GEMI) in pure and dosage forms. It has absorption maximum at 343 nm and obeys beer’s law in the concentration range 2-20 μg mL-1 .Results of analysis were validated statistically and by recovery studies .The apparent molar absorptivity and sandell’s sensitivity were 1.3862×10⁴ L mol-1 cm-1 and 2.809×10-2 μg cm-2, respectively. The slope and intercept of the equation of the regression line are 0.05370 and -0.00640 respectively. Correlation coefficient was found to be 0.999. This method is successfully employed for the determination of Gemifloxacin in pharmaceutical preparation.

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